Med Sphere

 Living with diabetes: Here’s what you need to know before setting out to exercise Leading a healthy lifestyle is important, especially if you have been diagnosed with diabetes, which requires a lot of discipline in terms of what you eat and how active of a lifestyle you lead. The Centers for Disease Control and Prevention (CDC) defines diabetes as a “chronic (long-lasting) health condition that affects how your body turns food into energy”. It explains that the human body breaks down the food that we eat into sugar (glucose), and then releases it into the bloodstream. And that when the blood sugar goes up, it signals the pancreas to release insulin, which acts like a key to let the blood sugar into your body’s cells for use as energy. When someone is diagnosed with diabetes, their body does not make enough insulin or cannot use it as well as it should. And in the absence of sufficient insulin, too much blood sugar can stay in the bloodstream. The CDC warns that in case it is not t...

Could there soon be a nasal spray to help prevent COVID-19 infection?  e possibility of a mouth wash or nasal spray to prevent or reduce the spread of COVID-19 infections and its variants is being investigated by scientists at QUT, Griffith University and Xiamen University in China. The concept is based on cold atmospheric plasma (CAP), an ionized gas that has several emerging medical uses including decontamination of bacteria, enhanced wound healing, and treating cancers and skin infections. QUT Professor Rik Thompson, research lead for QUT at the Translational Research Institute and co-leader of the QUT Cancer Research Network, said viruses such as SARS-CoV-2 (that causes COVID-19) require the receptor protein ACE2 on cells' surface to bind to and enter and infect cells. "We found that a very brief exposure of cells to CAP caused the almost immediate loss of ACE2 from the cell surface, and this loss reduced the uptake of SARS-CoV-2 virus-like nanoparticles that bind the ACE2...

 A Case of Rhabdomyolysis in a Young, Morbidly Obese, Asthmatic Woman With COVID-19 Abstract COVID-19 is a respiratory disease that has been shown to have extrapulmonary manifestations. One association with COVID-19 is rhabdomyolysis, which is defined as the breakdown of skeletal muscles. There have been increasing reports of rhabdomyolysis in obese, middle-aged male COVID-19 patients, but limited published cases affecting young adult females. This case discusses the early presentation of rhabdomyolysis in a young, morbidly obese, asthmatic woman with COVID-19. A 28-year-old, unvaccinated, African American female with past medical history of asthma, tobacco abuse, and a BMI of 46 initially presented to the emergency department with a complaint of fever, cough, and shortness of breath for two days. She was initially diagnosed with an asthma exacerbation and was treated symptomatically, but her symptoms persisted despite treatment. She began to experience myalgias the next day, follo...

Licorice compounds proposed as effective candidates for treatment of COVID-19 Download PDF Copy A recent Frontiers in Pharmacology journal study utilizes bioinformatics, molecular docking, and molecular dynamics (MD) methods to determine the efficacy of licorice in managing coronavirus disease 2019 (COVID-19). More specifically, the researchers describe the different mechanisms by which licorice reduces the inflammatory response, inhibits tissue damage and cell death, regulates cell survival, and promotes tissue growth following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Background There is a lack of effective COVID-19 therapeutic agents with few side effects. However, numerous herbal medications appear to be effective in limiting the entry and replication of SARS-CoV-2 in host cells. Several studies have found that many active compounds within licorice, for example, can effectively neutralize SARS-CoV-2 and minimize COVID-19 symptoms. These effects are lik...

Engineered Antibody Shows Therapeutic Effects in Mouse Model of Alzheimer’s Disease A newly developed antibody that increases the activation of TREM2—a receptor on microglia—reduces amyloid burden and alleviates cognitive decline in mice exhibiting Alzheimer’s disease (AD) pathology. These findings indicate that the antibody, Ab18 TVD-Ig/aTfR, may have promise as a treatment for the disease. The work was led by Zhiqiang An, PhD, professor at McGovern Medical School at the University of Texas Health Science Center at Houston, and Ningyan Zhang, PhD, professor at the Texas Therapeutics Institute at the Brown Foundation Institute of Molecular Medicine. Their team published their work in Science Translational Medicine in an article entitled, “A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer’s disease.” Alzheimer’s disease, which is characterized by the loss of memory and thinking skills, affects more than 10% of the elderly population. Amyloid-...

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